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Noncompartmental analysis of Bup-HCl and Bup-SR in guinea pigs
| Cmax (ng/mL) | Tmax (h) | t1/2 (h) | AUClast (h × ng/mL) | Tlast (h) | Cl/Fpred (mL/h/kg) | |
| Bup-SR (overall) | 1344 | 26 | 25.3 | 56,996 | 72 | 4.24 |
| Bup-HCl (0–12 h) | 2331 | 1 | 6.63 | 4,050 | 12 | 8.38 |
| Bup-SR (0–12 h) | 1261 | 6 | n.d. | 11,593 | 12 | not done |
Cmax, maximal concentration measured; Tmax, time of Cmax; t1/2, terminal half-life; AUClast, AUC from time 0 to Tlast; Tlast, time point to which AUClast was calculated; Cl/Fpred, predicted clearance.
