Table 1.
The general characteristics of the included studies in the current meta-analysis
| Gene | First author | Country | Ethnicity | Method | Histology | Sample | Cancer
|
Control
|
OS | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| M+ % | Total | M+ % | Total# | ||||||||
| p14ARF | Jarmalaite et al31 (2003) | Finland | Caucasians | MSP | NSCLC | Tissue | 8.7 | 46 | 2 | 51 | |
| Topaloglu et al30 (2004) | USA | Caucasians | QRTPCR | NSCLC | BALF | 0 | 31 | 0 | 10 | ||
| Fischer et al29 (2007) | Germany | Caucasians | MSP | NSCLC | Blood | 30.4 | 92 | 0 | 14 | 0.57 (0.19–1.73) | |
| Yanagawa et al23 (2007) | Japan | Asians | MSP | NSCLC | Tissue | 7.9 | 101 | 0.99 | 101 | ||
| De Jong et al28 (2009) | the Netherlands | Caucasians | MSP | NSCLC | BALF | 0 | 10 | 0 | 18 | ||
| Zhang et al24 (2011) | China | Asians | MSP | NSCLC | Tissue | 6.4 | 78 | 1.3 | 78 | ||
| Tian et al32 (2006) | China | Asians | MSP | NSCLC | Tissue | 17.5 | 40 | 2.5 | 40 | ||
| Hu et al33 (2014) | China | Asians | MSP | NSCLC | Tissue | 33.6 | 107 | 12.1 | 107 | ||
| p15INK4B | Chaussade et al35 (2001) | France | Caucasians | MSP | NELC | Tissue | 100 | 20 | 95 | 20 | |
| Seike et al21 (2000) | Japan | Asians | MSP | LC | Tissue | 0 | 27 | 0 | 27 | ||
| Shimamoto et al34 (2004) | Japan | Asians | MSP | NSCLC | Tissue | 11.1 | 45 | 0 | 10 | ||
| Wang et al22 (2008) | China | Asians | 3DPCR | NSCLC | Tissue | 7.1 | 28 | 0 | 12 | ||
Note:
#
Total is the number of lung cancer or nontumor samples.
Abbreviations: 3DPCR, 3-dimensional (3-D), polyacrylamide gel-based DNA microarray coupled with linker-polymerase chain reaction; BALF, bronchoalveolar lavage fluid; LC, lung cancer; M+, methylation positive status; MSP, methylation-specific polymerase chain reaction; NELC, neuroendocrine lung cancer; NSCLC, non-small-cell lung cancer; OS, overall survival; QRTPCR, quantitative fluorogenic real-time PCR.