Table 1.
Characterization of SAHA-S-S-VE aggregates under different conditions
| Formulation | Diameter (nm) | PDI | Zeta (mV) | Morphology |
|---|---|---|---|---|
| SAHA-S-S-VE | 148.2±6.3 | 0.111±0.038 | −25.7±4.1 | Nanoparticles |
| SAHA-S-S-VE (w/w, F68/SAHA-S-S-VE: F68 100%, 20%, 10%) | NA | NA | NA | No aggregation or precipitation |
| SAHA-S-S-VE (TPGS 30%) | 153.4±7.0 | 0.046±0.007 | −8.2±0.8 | No aggregation |
| SAHA-S-S-VE (TPGS 15%) | 167.4±3.4 | 0.068±0.025 | −10.2±0.8 | Nanoparticles |
| SAHA-S-S-VE (TPGS 15%) 30 days later | 160.8±4.5 | 0.072±0.019 | −8.0±1.1 | Nanoparticles |
Note: Data presented as mean ± SD.
Abbreviations: NA, not applicable; TPGS, d-a-tocopheryl polyethylene glycol succinate; PDI, polydispersity index.