Table 2.
In vitro cell growth inhibition assay
| Formulation | Xlog Pa | IC50 (μM)b
|
|||
|---|---|---|---|---|---|
| MDA-MB-231 | PC-3 | HepG2 | A549 | ||
| SAHA | 2.97 | 3.50±0.90 | 2.99±0.23 | 12.8±1.1 | 10.7±2.0 |
| SAHA-S-S-VE | 12.44 | 2.02±0.42* | 2.21±0.26 | 7.98±1.64* | 1.99±0.29* |
| SAHA-O-VE | 11.46 | 6.09±0.50 | 5.27±1.00 | 10.7±1.6 | 17.4±2.1 |
| NH2-S-S-VE | Not tested | >30 | >30 | >30 | >30 |
| SAHA-S-S-VE/TPGS NPs | Not tested | 3.03±0.71 | 1.85±0.21* | 6.30±0.59** | 6.66±0.53* |
Notes:
a
The Xlog P was calculated using the method reported by Cheng et al.57
b
All of the compounds were assayed three times, and their inhibition results were means of the three independent assays and expressed with standard deviations.
Statistical significance:
*
P<0.05 vs SAHA,
**
P<0.01 vs SAHA.
Abbreviations: IC50, half maximal inhibitory concentration; TPGS, d-a-tocopheryl polyethylene glycol succinate; NP, nanoparticle.