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(A) Model of restored 5-LO WT [30] based on Stable-5LOX [10], C2-like domain (blue), catalytic domain (grey), ATP binding site (yellow), non-heme iron and coordinating amino acids (red), missing amino acids (Trp144-Ala184) in 5-LOΔ4 (orange) nuclear import sequences (green spheres) (B) cation– π interaction and salt bridge between R101, W102, R165, D166 (green sticks) (C) FY cork F177, Y181 (pink).
