Fig. 7.

Mitochondrial H₂S donors increase the respiratory Complex II/III activity. A and B: Cytochrome c reduction was monitored in bovine heart mitochondria following Complex I and IV blockade by rotenone and KCN, respectively. A: AP39 was added at 10 nM–10 μM and complex II/III activity was measured kinetically, B: Mitochondria were treated with AP123 (10 nM–10 μM) and the respiratory complex activity was monitored. (*p < 0.05, H₂S donors significantly increased the respiratory complex activity).