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. Author manuscript; available in PMC: 2017 Mar 7.
Published in final edited form as: Int J Obes (Lond). 2016 Sep 7;40(11):1768–1775. doi: 10.1038/ijo.2016.157

Figure 5.

Figure 5

Effect of maternal food restriction (MFR) on the adipogenic differentiation potential of bone marrow-derived mesenchymal stem cells (BMSCs). (A) Compared with the control BMSCs, MFR BMSCs showed 5-fold increase in adipogenic potential, as determined by the ratio of the number of differentiated adipocytes (positive ORO staining)/total cell number per mm2. (B) Although at baseline compared to the controls, the mRNA levels of key adipogenic markers were already higher, following adipogenic induction, the levels of adipogenic genes PPARγ (29-fold), LPL (36-fold) and ADRP (267-fold) increased significantly in the MFR group vs. the control group, whereas, in contrast, RUNX2 mRNA expression was 4-fold lower in MFR BMSCs compared to controls (N=3, *p<0.05, ***p<0.01 vs. control).