Table 1.
Adult and Adolescent Soy Protein Intake and Breast Cancer Risk By Menopausal Status
| Soy Protein Intake Level (RRa,b (95%CI)) |
||||||
|---|---|---|---|---|---|---|
| Quintile 1 | Quintile 2 | Quintile 3 | Quintile 4 | Quintile 5 | Ptrend | |
| ADULT INTAKE (median(g/day)) | 3.5 | 6.0 | 8.2 | 10.9 | 16.0 | |
| Overall | 1.00 (reference) | 1.01 (0.83, 1.22) | 1.00 (0.82, 1.21) | 0.87 (0.71, 1.06) | 0.78 (0.63, 0.97) | 0.007 |
| N(cases) | 212 | 222 | 222 | 196 | 182 | |
| Premenopausalc (N(cases)=273) | 1.00 (reference) | 0.97 (0.69, 1.36) | 0.86 (0.60, 1.24) | 0.98 (0.68, 1.42) | 0.46 (0.29, 0.74) | 0.004 |
| N(cases) | 68 | 65 | 54 | 59 | 27 | |
| Postmenopausalc (N(cases)=761) | 1.00 (reference) | 1.03 (0.82, 1.30) | 1.06 (0.84, 1.33) | 0.83 (0.65, 1.06) | 0.90 (0.71, 1.16) | 0.15 |
| N(cases) | 144 | 157 | 168 | 137 | 155 | |
|
ADOLESCENT INTAKE
(median(g/day)) |
1.8 | 3.9 | 6.2 | 9.2 | 15.6 | |
| Overall | 1.00 (reference) | 1.04 (0.86, 1.26) | 1.12 (0.92, 1.35) | 1.04 (0.86, 1.26) | 0.95 (0.77, 1.16) | 0.43 |
| N(cases) | 198 | 213 | 226 | 212 | 185 | |
| Premenopausalc | 1.00 (reference) | 0.77 (0.54, 1.11) | 0.96 (0.68, 1.36) | 0.74 (0.51, 1.07) | 0.69 (0.45, 1.04) | 0.08 |
| N(cases) | 63 | 55 | 69 | 51 | 35 | |
| Postmenopausalc | 1.00 (reference) | 1.17 (0.93, 1.47) | 1.19 (0.94, 1.49) | 1.18 (0.94, 1.49) | 1.06 (0.84, 1.34) | 1.00 |
| N(cases) | 135 | 158 | 157 | 161 | 150 | |
a
Cox proportional hazards models adjusted for age, body mass index, age at first live birth, physical activity, education, family history of breast cancer, season of recruitment, and menopause (time-varying) were used for analyses
b
Adult intakes additionally adjusted for total energy intake and juvenile intakes adjusted for total juvenile rice intake
c
Stratified based on menopausal status at breast cancer diagnosis