Table 3.
Joint Effect of Adult and Adolescent Soy Protein Intake on Breast Cancer Risk
| Adult Average Soy Protein Intake (RRa (95%CI)) |
|||
|---|---|---|---|
| Juvenile Soy Protein Intake | ≤6.32 | 6.33-10.43 | ≥10.44 |
| Premenopausalb (N(cases)=273) | |||
| ≤4.24 | 1.00 (reference) | 0.62 (0.38, 1.00) | 0.56 (0.31, 1.02) |
| 4.25-8.61 | 0.86 (0.58, 1.28) | 0.86 (0.57, 1.29) | 0.78 (0.49, 1.25) |
| ≥8.62 | 0.56 (0.31, 1.00) | 0.80 (0.51, 1.26) | 0.53 (0.32, 0.88) |
| Postmenopausalb (N(cases)=761) | |||
| ≤4.24 | 1.00 (reference) | 0.96 (0.72, 1.29) | 0.63 (0.43, 0.91) |
| 4.25-8.61 | 1.07 (0.81, 1.43) | 1.08 (0.82, 1.43) | 0.94 (0.69, 1.26) |
| ≥8.62 | 0.94 (0.67, 1.32) | 1.01 (0.76, 1.35) | 0.98 (0.74, 1.29) |
a
Cox proportional hazards models adjusted for age, body mass index, age at first live birth, physical activity, education, family history of breast cancer, season of recruitment, total adult energy, total juvenile rice intake, and menopause (time-varying) were used for analyses
b
Stratified based on menopausal status at breast cancer diagnosis