Table 1.
B. burgdorferi flaB (103 copies per mg tissue)
|
|||||
---|---|---|---|---|---|
Bladder | Heart | Joint | Liver | Spleen | |
WT | 16.8 ± 0.2 | 20.4 ± 1.7 | 2.3 ± 0.3 | 23.0 ± 9.4 | 10.5 ± 0.8 |
+CLL, WT | 48.0 ± 0.2*** | 31.6 ± 1.5** | 12.9 ± 0.8** | 52.2 ± 5.7 | 25.9 ± 3.6* |
−Spl, WT | 12.8 ± 1.2 | 17.8 ± 1.2 | 2.1 ± 0.4 | 36.8 ± 1.2 | – |
Cd1d−/− | 23.7 ± 1.5* | 10.4 ± 1.9* | 59.4 ± 0.6*** | 36.2 ± 1.1 | 10.9 ± 0.6 |
B. burgdorferi clearance in untreated, CLL-treated or splenectomized wild-type mice and in Cd1d−/− mice at 3 d after B. burgdorferi infection, assessed by quantitative PCR analysis of B. burgdorferi flaB (pooled DNA samples).
P < 0.05,
P < 0.01 and
P < 0.001, versus wild-type (Bonferroni’s mutiple-comparison test).
Data represent one experiment with three to five mice, depending on experimental group (mean and s.e.m. of two independent measurements).