Table 1.
Nine of the 1000 SNPs with the lowest p-values in a GWAS for AN risk (GCAN9) are associated with increased BMI (GIANT11, with Bonferroni-corrected P < 0.05 significance; sorted according to the nominal p-values for increased BMI in all GIANT participants)
| Chromosome/position SNP nearest gene(s) |
Location | Rank in AN GWAS | AN effect allele/frequency in AN cases | Odds Ratio (SE) | p-value for AN risk | Frequency of AN reference allele for BMI | β (se) for BMI for reference allele | Nominal p-value for increased BMI: all female/male | Bonferroni corrected p-valuea | Direction of effectb +/− |
|---|---|---|---|---|---|---|---|---|---|---|
| 10/126685663 rs1561589 CTBP2 |
Intron | 201 | A / 0.33 | 1.14 (0.04) | 7.74 × 10−05 | A / 0.34 | 0.0157 (0.0033) | 2.47 × 10−06 3.45 × 10−07 / 0.043 |
0.0025 | + |
| 10/126681170 rs12771627 CTBP2 |
Intron | 190 | G / 0.75 | 0.87 (0.03) | 7.28 × 10−05 | G / 0.74 | −0.0162 (0.0035) | 4.25 × 10−06 5.8 × 10−06 / 0.022 |
0.0043 | + |
| 10/126674064 rs11245456 CTBP2 |
Intron | 177 | C / 0.75 | 0.87 (0.03) | 6.79 × 10−05 | C / 0.75 | −0.0171 (0.0037) | 4.58 × 10−06 1.03 × 10−05 / 0.009 |
0.0046 | + |
| 19/34978662 rs17513613 CCNE1 |
Distant 5′ | 409 | T / 0.70 | 0.88 (0.03) | 0.0002 | T / 0.67 | −0.015 (0.0033) | 5.41 × 10−06 6.4 × 10−03 / 1.24 × 10−05 |
0.0054 | + |
| 2/203492447 rs17406900 CARF |
Intron | 709 | A / 0.48 | 0.90 (0.03) | 0.0003 | A / 0.49 | −0.0134 (0.0031) | 1.08 × 10−05 1.8 × 10−04 / 2.27 × 10−03 |
0.0108 | + |
| 2/203639257 rs7593917 NBEAL1 |
Intron | 444 | A / 0.46 | 0.89 (0.03) | 0.0002 | A / 0.46 | −0.0131 (0.0031) | 2.48 × 10−05 9.54 × 10−05 / 9.39 × 10−03 |
0.0248 | + |
| 2/203582157 rs11691351 NBEAL1 |
Distant 5′ | 412 | A / 0.46 | 0.89 (0.03) | 0.0002 | A / 0.46 | −0.0126 (0.0031) | 3.57 × 10−05 1.98 × 10−04 / 8.21 × 10−03 |
0.0357 | + |
| 19/34988693 rs8102137 CCNE1 |
Distant 5′ | 248 | T / 0.70 | 0.88 (0.03) | 9.45 × 10−05 | T / 0.67 | −0.0169 (0.0041) | 3.76 × 10−05 0.006 / 2.46 × 10−04 |
0.0376 | + |
| 2/203635796 rs7573079 NBEAL1 |
Intron | 401 | G / 0.46 | 0.89 (0.03) | 0.0002 | G / 0.46 | −0.0124 (0.0031) | 4.61 × 10−05 2.80 × 10−04 / 0.008 |
0.0461 | + |
a
primary analysis, sex-combined, correction for 1,000 tests
b
Direction of effect: + the effect/risk allele for increased BMI and AN risk are identical; − the effect/risk allele for increased BMI and AN risk are not identical.
Gene abbreviations (alphabetically): ALS2CR8 (amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8), CARF (Calcium Responsive Transcription Factor); CCNE1 (cyclin E1), CTBP2 (C-terminal binding protein 2), NBEAL1 (neurobeachin-like 1)