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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Ageing Res Rev. 2016 May 17;33:67–75. doi: 10.1016/j.arr.2016.05.005

Figure 1. Clinical symptoms and cellular phenotypes of FA symptomatic of accelerated aging.

Figure 1

FA patients face many health issues in their childhood (teens) and early adulthood (twenties) that also challenge healthy individuals as they age into their fifties and sixties. These include but are not limited to: a dysfunctional bone marrow leading to anemia and immunodeficiency, chronic inflammation, as wells as squamous cell carcinomas and acute myeloid leukemia. Another set of clinical features shared by aging individuals and FA patients are: a decline in endocrine functions, sarcopenia and osteopenia.