Table 1.
Baseline characteristics in the propensity score-matched cohort
| Baseline characteristics | Propensity score-matched cohort | |
|---|---|---|
| KR patients (N=14 042) |
Non-KR patients (N=14 042) |
|
| Sociodemographics | ||
| Age, years | 70.9 | 70.9 |
| Sex, % male | 43.8 | 43.5 |
| BMI, kg/m2 | 29.2 | 29.2 |
| Socioeconomic Deprivation Index Score* | 2.6 | 2.6 |
| OA characteristics | ||
| OA duration, years | 5.3 | 5.3 |
| Lifestyle factors | ||
| Smoking | ||
| Current, % | 7.9 | 7.7 |
| Past, % | 33.2 | 33.8 |
| None, % | 58.9 | 58.5 |
| Alcohol use | ||
| Current, % | 79.7 | 80.7 |
| Past, % | 2.4 | 2.2 |
| None, % | 17.9 | 17.1 |
| Measures of comorbidity | ||
| Atrial fibrillation, % | 5.9 | 5.9 |
| Cancer, % | 12.4 | 12.2 |
| Cellulitis, % | 15.1 | 15.2 |
| Charlson Comorbidity Index | 0.5 | 0.5 |
| Chronic obstructive pulmonary disease, % | 3.7 | 3.8 |
| Chronic kidney disease, % | 9.2 | 9.2 |
| Congestive heart failure, % | 2.7 | 2.7 |
| Dementia, % | 0.4 | 0.4 |
| Depression, % | 12.2 | 11.5 |
| Diabetes, % | 13.0 | 12.8 |
| High fall risk, % | 15.3 | 15.4 |
| Hip fracture, % | 0.9 | 0.8 |
| Hyperlipidaemia, % | 18.5 | 18.3 |
| Hypertension, % | 56.5 | 57.0 |
| Ischaemic heart disease | ||
| Angina, % | 7.3 | 7.1 |
| Myocardial infarction, % | 1.5 | 1.7 |
| Postsurgery for coronary disease, % | 2.2 | 2.1 |
| Other cardiomyopathy, % | 4.9 | 4.9 |
| Liver disease, % | 2.2 | 2.2 |
| Other circulatory disease, % | 26.6 | 26.3 |
| Peripheral vascular disease, % | 1.3 | 1.4 |
| Pneumonia or other infections, % | 7.6 | 7.6 |
| Seizure, % | 0.4 | 0.4 |
| Stroke, % | 2.9 | 2.9 |
| Transient ischaemic attack, % | 3.4 | 3.3 |
| Valvular heart disease, % | 2.5 | 2.6 |
| Varicose veins, % | 15.5 | 15.1 |
| Venous thromboembolism, % | 4.9 | 5.0 |
| Medications | ||
| ACE inhibitors, % | 26.6 | 27.0 |
| Angiotensin receptor blockers (other than losartan), % | 8.3 | 8.3 |
| Anticoagulant, % | 4.8 | 4.6 |
| Antihypertensive medicine, % | 63.2 | 63.4 |
| Antiseizure medicine, % | 3.9 | 3.8 |
| Aspirin, % | 28.0 | 27.7 |
| β-Blockers, % | 22.4 | 22.3 |
| Bisphosphonates, % | 4.7 | 4.8 |
| Calcium channel blockers, % | 27.4 | 27.7 |
| Glucocorticoids, % | 17.2 | 17.1 |
| Hydrochlorothiazides, % | 25.5 | 25.8 |
| Insulin, % | 1.8 | 1.7 |
| Lipid-lowering, % | 36.6 | 37.2 |
| Loop diuretics, % | 10.8 | 10.8 |
| Losartan, % | 3.2 | 3.0 |
| Nitrate, % | 6.2 | 6.3 |
| NSAIDs, % | 54.4 | 54.7 |
| Opioid analgesics, % | 59.7 | 59.8 |
| Other analgesics (paracetamol, tramadol), % | 41.2 | 41.1 |
| Oral antidiabetics, % | 8.1 | 7.9 |
| Potassium sparing diuretics, % | 3.4 | 3.5 |
| Raloxifene, % | 0.2 | 0.2 |
| Strontium, % | 0.1 | 0.1 |
| Thiazide-like diuretic, % | 3.3 | 3.0 |
| Healthcare usage† | ||
| General practice visit | 13.7 | 13.7 |
| Hospitalisation | 0.9 | 0.9 |
| Referral | 1.7 | 1.6 |
| Number of medication prescribed | 2.8 | 2.9 |
*
Socioeconomic Deprivation Index Score was measured by the Townsend Deprivation Index, which was grouped into quintiles from 1 (least deprived) to 5 (most deprived).
†
Frequency during the last 2 years.
BMI, body mass index; KR, knee replacement; NSAID, non-steroidal anti-inflammatory drug; OA, osteoarthritis.