Table 1.
Xanthine oxidase inhibition of Indian Muscodor species by qualitative and quantitative assay
| Treatment | % XO inhibition | % Reduction in uric acid production | |
|---|---|---|---|
| Xanthine plate assay | NBT assay | ||
| Control (no inhibitor) | 0e | 0g | 0g |
| Febuxostat* | 59.4 ± 1.0a | 99.2 ± 0.0a | 99.5 ± 0.0a |
| M. darjeelingensis | 59.4 ± 1.0a | 91.4 ± 0.8b | 88.1 ± 0.0b |
| Allopurinol* | 58.6 ± 1.0a | 88.0 ± 0.5b | 86.7 ± 0.0b |
| M. tigerii | 56.7 ± 0.9a | 77.0 ± 0.5c | 74.0 ± 0.0c |
| M. kashayum | 54.9 ± 1.0a | 76.0 ± 1.0c | 70.3 ± 0.0c |
| M. strobelii | 48.6 ± 3.1b | 40.2 ± 1.9e | 40.2 ± 2.6d |
| M. camphora | 46.7 ± 1.8b | 46.7 ± 1.8d | 39.7 ± 0.0d |
| M. ghoomensis | 31.6 ± 3.8c | 37.6 ± 2.7e | 24.2 ± 0.0e |
| M. indica | 18.2 ± 1.9d | 28.6 ± 4.5f | 18.7 ± 1.6f |
* Represent commercial inhibitors of Xanthine Oxidase (XO). All values presented are Mean ± SD of triplicate readings
Mean values represented by same alphabets are not significantly different by Tukey’s post hoc analysis at p ≤ 0.05