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. 2016 Jul 29;92(7):222–236. doi: 10.2183/pjab.92.222

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© 2016 The Japan Academy

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Mode of production of heteroclitic (top) or of authentic anti-poly(ADP-ribose) antibody (bottom) by oligo(ADP-ribosyl)ated histone (top) or by poly(ADP-ribosyl)ated histone (bottom). Here, histone H1 is shown as a representative. Antibody induced even by oligoADP-ribosylated histone preferred poly(ADP-ribose) but not oligomer of ADP-ribose (top). Whereas antibody induced or produced by poly(ADP-ribose) preferred the relevant antigen poly(ADP-ribose) but not oligomer of ADP-ribose (bottom). That is why the former is “Heteroclitic”. This illustration was constructed according to our original papers referred to as Refs. 56 and 57.