Table 2.

Observed vs. predicted average QT intervals

		QT interval [ms]
		Observed	Predicted suma	Predicted Blissa	Predicted Loewea
Fluoxetine [1]	BL	372.4	396.0
	T	374.9	398.5
	I	–	400.9
	T + I	379	401.6	400.8	400.2
		Distance	1.49	2.59	3.34
Erythromycin [15]	BL		392.8
	T2	8	398.5
	Ib	21	403.7
	T + Ib	39	418.2	413.6	411.4
		Distance	18.38	22.75	25.13
Fluconazole [16]	BL	398.5	395.2
	T	398.4	401.3
	I		414.3
	T + I	411	422.6	418.6	416.8
		Distance	31.28	26.02	23.65
Itraconazolec [17]	BL	376	430.5
	T	390	438
	I	No effect	486.9
	T + I	417	452.2	448.9	447.3
		Distance	24.05	28.50	30.68
Ketoconazole [18]	BL	408	394.5
	T	416	395
	I	–	415.4
	T + I	490	439	427.9	423.6
		Distance	48.61	64.03	70.14
Clarithromycin [19]	BL	409	395.5
	T	410	401.4
	I	407	393.9
	T + I	430	404.4	403.8	402.7
		Distance	21.43	22.96	23.79
Erythromycin [19]	BL	394	397.5
	T	408	403.7
	I	409	405.8
	T + I	428	420.1	415.6	413.5
		Distance	14.27	19.46	22.17
Paroxetine [25]	BL	381	392.0
	T	387	394.5
	I	–	393.5
	T + I	386	396.6	393.6	396.8
		Distance	4.69	4.86	4.78

In bold - the best fitted model (the lowest distance value)

BL baseline, T terfenadine, I inhibitor

^aDDI effect on ion channels calculation method

^bOnly QT change reported in the study

^cMaximal QT change