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. 2016 Oct 21;78(6):1175–1184. doi: 10.1007/s00280-016-3174-8

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Age dependency of doxorubicin clearance. Distribution of clearance (CL) (normalized to BSA) for the two investigated age groups (A: <3 years and B: 3 to <18 years). Data are summarized as box-and-whisker plots. In each plot, the central box represents values from the lower to upper quartile (25–75 percentiles) and the middle line the median. The end of the upper whisker corresponds to the largest observation smaller than the 75 % quantile + 2*IQR. Likewise, the end of the lower whisker corresponds to the smallest observation larger than the 25 % quantile − 2*IQR. Observations that are beyond the whiskers can be regarded as outliers