Table 3.

Effects of chakasaponins I (11)—III (13) and escin IIa on plasma triglyceride (TG) and glucose elevations in olive oil and sucrose-loaded mice.

Data were taken and reproduced from reference [12]

Treatment	Dose (mg/kg, p.o.)	Plasma TG (mg/100 mL) at 2.0 h	Plasma glucose (mg/100 mL) at 0.5 h
Normal	–	115.5 ± 12.4**	128.5 ± 5.3**
Control	–	440.5 ± 45.2	226.9 ± 8.2
Chakasaponin I (11)	25	435.7 ± 67.4	–
	50	284.2 ± 9.6**	199.6 ± 8.7**
	100	–	196.8 ± 8.2**
Normal	–	152.4 ± 13.5**	116.5 ± 7.9**
Control	–	553.8 ± 49.8	221.5 ± 14.4
Chakasaponin II (12)	25	431.8 ± 49.8**	–
	50	249.5 ± 31.1**	185.7 ± 9.9**
	100	–	178.5 ± 8.3**
Normal	–	124.0 ± 8.4**	126.5 ± 4.0**
Control	–	407.2 ± 73.0	238.7 ± 5.9
Chakasaponin III (13)	25	394.1 ± 81.4	–
	50	214.4 ± 62.7*	215.9 ± 10.6**
	100	–	189.0 ± 10.2**
Normal	–	91.9 ± 9.4**	–
Control	–	440.3 ± 60.2	–
Orlistat	5	371.3 ± 41.5	–
	10	203.8 ± 52.1**	–
Normal	–	–	124.8 ± 7.3**
Control	–	–	218.7 ± 4.0
Acarbose	10	–	162.4 ± 11.7**
	20	–	153.8 ± 10.2**
Normal	–	114.9 ± 18.1**	122.2 ± 6.3**
Control	–	546.7 ± 59.4	263.3 ± 16.2
Escin IIa	50	464.2 ± 45.3	254.2 ± 14.0
	100	308.9 ± 61.4*	206.4 ± 12.9**

Effects on plasma TG levels in mice: each test sample was given orally to fasted male ddY mice and olive oil (5 mL/kg, p.o.) was given 30 min later. Blood samples were collected at 2, 4, and 6 h after olive oil treatment. Plasma TG levels were determined by an enzymatic method using a commercially available kit

Effects on plasma glucose levels in mice: each test sample was given orally to fasted male ddY mice, and a 10 (w/v) % sucrose solution (10 mL/kg, p.o.) was given 30 min later. Blood samples were collected at 0.5, 1, and 2 h after sucrose loading. Plasma glucose levels were determined by an enzymatic method using a commercially available kit

Values represent the mean ± SEM (n = 5–9)

Significant difference where *p < 0.05 or **p < 0.01 was compared with controls