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Mechanotransduction through integrins and primary cilia. (A) Cell cytoskeleton senses loading at the membrane through integrins that transmit force through ERK, Src and RoA to stress fiber polymerization. (B) Primary cilia may sense flow shear strain, activating ion flux through PC1 and TRPV4, which can activate Stat signals. Cilia also modulate Wnt signaling via non-canonical pathway that leads to β-catenin degradation.
