FIGURE 4.

Deficiency in the R838S RetGC1 rod vision develops from early age. A, waveforms of dark-adapted (scotopic) ERG evoked in R838S⁺ (red traces) mice from the slower line 379 and their wild type littermates (black traces) by 505-nm flashes of increasing strength (top to bottom): 1.9, 6.6, 17, 133, 1.1 × 10³, 4 × 10³, and 1.1 × 10⁶ R*/rod; recorded at 1, 3, or 6 months of age as indicated. B, amplitudes of scotopic a-wave (left) and b-wave (right) in 10 1-month-old R838S⁺ (red symbols) and 8 wild type littermates (black symbols), plotted as a function of the flash strength: 1.9, 3.3, 6.6, 10, 17, 133, 1.1 × 10³, 4.3 × 10³, 34 × 10³ and 1.1 × 10⁶ R*/rod. The asterisks indicate a statistically significant difference between the two genotypes at various flash strengths: p < 0.05 (*), p < 0.01 (**), and p < 0.0001 (***).