FIGURE 1.

Alignment of the N-terminal cytosolic sequences of the members of the Deg/ENaC family from Rattus norvegicus. Residues conserved between all members are highlighted in red, and residues conserved between BASIC and at least five members are highlighted in green. The first transmembrane domain is indicated by a box (TMD1); only few amino acids close to TMD1 show high conservation. Accession numbers are as follows: NP_071563, BASIC; NP_077068, ASIC1a; XP_008764015, ASIC1b; NP_001029186, ASIC2a; NP_037024, ASIC2b; NP_775158, ASIC3; NP_071570, ASIC4; NP_113736, αENaC; NP_036780, βENaC; NP_058742, γENaC. Alignment was performed using Clustal W version 2.1.