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Osteogenic genes with a reduction in H3K27me3 and exhibiting enhanced expression with Ezh2 inhibition. We examined RNA-seq data (see Fig. 2) for genes exhibiting up-regulation in gene expression after GSK126 treatment. The genes presented here show decreased H3K27me3 levels (based on ChIP-seq data from Fig. 4) and focuses primarily on genes that modulate osteogenesis through transcriptional regulation and cell signaling mechanisms.
