TABLE 1.
Summary of biochemical and cell assay results
| ML364 | Compound 2 | |
|---|---|---|
| USP2 Di-Ub IQF Lys-48-l4 (IC50) | 1.1 μm | Inactive |
| USP2 Di-Ub IQF Lys-63-3 (IC50) | 1.7 μm | Inactive |
| HCT116 cell viability (EC50) | 3 μm | Inactive |
| Mino cell viability (EC50) | 4.7 μm | Inactive |
| HCT116 Clonogenic (EC50) | 3.6 μm | Inactive |
| HCT116 Acumen cell cycle (EC50) | 2 μm | Inactive |
| HCT116 flow, cell cycle | Arrest in G1 | Inactive |
| Mino flow, cell cycle | Arrest in G1 | Inactive |
| Western HCT116, cyclin D1 destabilization | 0.97 μm | Inactive |
| Western Mino, cyclin D1 destabilization | 8.5 μm | Inactive |
| Caspase 6 (IC50) | Inactive | Inactive |
| Caspase 7 (IC50) | Inactive | Inactive |
| USP8 Di-Ub IQF Lys-48-2 (IC50) | 0.95 μm | Inactive |
| USP20 Di-Ub IQF Lys-48-2 (IC50) | Inactive | Inactive |
| MMP1 (IC50) | Inactive | NDa |
| MMP9 (IC50) | Inactive | ND |
| 102 kinases screened at 10 μm | Inactive | ND |
a ND means not determined.