TABLE 2.

Kinase competition binding for ML364 from Kinomescan

Entrez gene symbol	Percent control	Entrez gene symbol	Percent control	Entrez gene symbol	Percent control
ABL1	100	EPHA2	90	PAK2	100
ABL1	82	ERBB2	100	PAK4	98
ABL1	90	ERBB4	99	CDK16	96
ABL1	90	MAPK3	100	PDGFRA	91
ACVR1B	94	PTK2	100	PDGFRB	95
CABC1	84	FGFR2	85	PDPK1	100
AKT1	92	FGFR3	88	PIK3C2B	79
AKT2	56	FLT3	71	PIK3CA	87
ALK	68	GSK3B	100	PIK3CG	89
AURKA	87	IGF1R	88	PIM1	94
AURKB	87	CHUK	83	PIM2	100
AXL	62	IKBKB	79	PIM3	90
BMPR2	85	INSR	81	PRKACA	95
BRAF	82	JAK2	75	PLK1	98
BRAF	94	JAK3	98	PLK3	78
BTK	84	MAPK8	88	PLK4	83
CAMK2B	93	MAPK9	84	PRKCE	88
CDK19	100	MAPK10	84	RAF1	93
CDK2	100	KIT	97	RET	92
CDK3	88	KIT	85	RIOK2	100
CDK4	88	KIT	96	ROCK2	89
CDK4	81	STK11	100	RPS6KA3	100
CDK5	100	MAP3K4	73	NUAK2	72
CDK7	76	MAPKAPK2	81	SRC	96
CDK8	100	MARK3	83	SRPK3	96
CDK9	93	MAP2K1	89	TGFBR1	100
CHEK1	84	MAP2K2	84	TEK	98
CSF1R	100	MET	90	NTRK1	100
CSNK1D	100	MKNK1	69	TSSK1B	44
CSNK1G2	98	MKNK2	100	TYK2	83
DCLK1	100	MAP3K9	92	ULK2	81
DYRK1B	100	MAPK14	92	KDR	79
EGFR	86	MAPK11	95
EGFR	95	PAK1	99