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ADME properties of ML364
| Aqueous kinetic solubility (pH 7.4, PBS buffer)a | Aqueous kinetic solubility (pH 8, DiUb assay buffer without β-mercaptoethano)a | Aqueous stability (2% DMSO, 15% MeCN, 83% pH 8 DiUb assay buffer) | LogD (measured at pH 7.4, PBS buffer)b | PAMPA permeabilitya | |
|---|---|---|---|---|---|
| ML364 | <2 μm | 28.9 μm | >48 h | 2.31 | 82.2 × 10−6 cm/s |
a Performed in-house.
b Contracted to Analiza, Inc.
