TABLE 1.
Sequence identity of mammalian complex I relative to human (left) and bovine (right)
| Subunits, “Human Nomenclature” | Bovine | Ovine | Porcine | Subunits, ”Common Bovine Nomenclature” | Ovine | Porcine |
|---|---|---|---|---|---|---|
| Core | ||||||
| NDUFV1 | 97.5 | 98.0 | 97.5 | 51 kDa | 99.5 | 98.7 |
| NDUFV2 | 98.6 | 98.2 | 97.2 | 24 kDa | 99.5 | 97.7 |
| NDUFS1 | 97.4 | 97.3 | 97.2 | 75 kDa | 99.3 | 96.7 |
| NDUFS2 | 95.4 | 95.6 | 95.8 | 49 kDa | 99.8 | 98.6 |
| NDUFS3 | 94.7 | 95.2 | 93.9 | 30 kDa | 97.4 | 95.2 |
| NDUFS7 | 92.7 | 92.7 | 92.2 | PSST | 100 | 96.1 |
| NDUFS8 | 96.0 | 96.0 | 96.0 | TYKY | 100a | 98.3 |
| Average nuclear | 96.0 | 96.1 | 95.7 | 99.4 | 97.3 | |
| ND1 | 78.0 | 78.0 | 77.0 | ND1 | 93.7 | 89.6 |
| ND2 | 63.1 | 63.1 | 62.0 | ND2 | 91.9 | 75.8 |
| ND3 | 73.9 | 73.0 | 71.3 | ND3 | 94.8 | 90.4 |
| ND4 | 74.1 | 75.2 | 73.2 | ND4 | 92.8 | 86.5 |
| ND4L | 73.5 | 76.5 | 76.5 | ND4L | 93.9 | 86.7 |
| ND5 | 69.5 | 69.6 | 69.5 | ND5 | 90.6 | 81.7 |
| ND6 | 62.3 | 61.1 | 57.7 | ND6 | 93.7 | 88.6 |
| Average mitochondria | 70.6 | 70.9 | 69.6 | 93.1 | 85.6 | |
| Supernumerary | ||||||
| NDUFS4 | 95.5 | 95.5 | 95.5 | 18 kDa | 98.5 | 95.5 |
| NDUFS5 | 74.3 | 70.5 | 79.0 | 15 kDa | 90.5 | 88.6 |
| NDUFS6 | 89.6 | 90.6a | 88.5 | 13 kDa | 97.9a | 93.8 |
| NDUFV3 | 86.7 | 88.0a | 29.3b | 10 kDa | 98.7a | 33.3b |
| NDUFA1 | 80.0 | 80.0 | 80.0 | MWFE | 95.7 | 81.4 |
| NDUFA2 | 93.9 | 93.9 | 94.9 | B8 | 100 | 94.9 |
| NDUFA3 | 83.1 | 83.1 | 78.3 | B9 | 98.8 | 85.5 |
| NDUFA5 | 87.0 | 87.0 | 87.8 | B13 | 98.3 | 94.8 |
| NDUFA6 | 90.6 | 90.6 | 89.0 | B14 | 98.4 | 92.9 |
| NDUFA7 | 88.4 | 87.5 | 90.2 | B14.5a | 96.4 | 92.0 |
| NDUFA8 | 87.7 | 87.1 | 90.6 | PGIV | 98.2 | 95.9 |
| NDUFA9 | 79.7 | 80.9 | 83.3 | 39 kDa | 96.2 | 87.8 |
| NDUFA10 | 80.6 | 79.7 | 79.7 | 42 kDa | 94.7 | 87.5 |
| NDUFA11 | 72.1 | 70.0 | 69.3 | B14.7 | 95.7 | 90.0 |
| NDUFA12 | 89.7 | 89.7 | 89.0 | B17.2 | 100 | 95.2 |
| NDUFA13 | 83.2 | 83.2 | 86.7 | B16.6 | 95.8 | 93.7 |
| NDUFAB1c | 97.7 | 97.7 | 96.6 | SDAPc | 100 | 98.9 |
| NDUFB1 | 82.5 | 77.2 | 82.5 | MNLL | 94.7 | 84.2 |
| NDUFB2 | 90.3 | 90.3 | 88.9 | AGGG | 100 | 95.8 |
| NDUFB3 | 82.5 | 83.5 | 84.5 | B12 | 99.0 | 95.9 |
| NDUFB4 | 73.4 | 75.0 | 78.1 | B15 | 93.8 | 87.5 |
| NDUFB5 | 85.3 | 85.5 | 100 | SGDH | 95.8 | 85.3 |
| NDUFB6 | 78.0 | 78.0 | 71.7 | B17 | 97.6 | 86.6 |
| NDUFB7 | 86.8 | 85.3 | 85.3 | B18 | 98.5 | 93.4 |
| NDUFB8 | 85.4 | 86.1 | 85.4 | ASHI | 98.7 | 93.0 |
| NDUFB9 | 91.0 | 89.3 | 91.1 | B22 | 96.6 | 93.3 |
| NDUFB10 | 78.5 | 78.0 | 77.4 | PDSW | 97.7 | 93.1 |
| NDUFB11 | 85.6 | 85.6 | 83.2 | ESSS | 98.4 | 90.4 |
| NDUFC1 | 81.6 | 79.6 | 83.7 | KFYI | 98.0 | 93.9 |
| NDUFC2 | 73.3 | 75.0 | 73.3 | B14.5b | 93.3 | 85.0 |
| Average | 84.5 | 83.9 | 83.1 | 97.2 | 89.5 | |
a The most reliable sequence was obtained from Ovis aries musimon subspecies genome.
b Porcine genomic sequence (NCB Gene ID, 100620809 (75)) shows an alternative predicted splice pattern compared with human, bovine, and ovine (NCB Gene IDs, 4731 (76),327717 (77) and 101105620) resulting in alternative C termini of the predicted protein and low sequence identity.
c Two copies of subunit NUDFAB1 (SDAP) are present in complex I giving a total of 45 subunits (11).