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FAD-dependent amine oxidases generate H2O2 to deaminate their substrates. The nuclear (nuc) amine oxidases KDM1A/B remove methyl groups from lysine residues on histone H3, as well as other nuclear proteins. The mitochondrial (mito) amine oxidases MAO-A/B catabolize small molecule amines such as neurotransmitters. All four enzymes share considerable structural homology and sequence identity (% seq ID) in their amine oxidase catalytic domains.
