Table 5.
Statistical Significance of Diagnostic Scores When Biomarkers Are Included One by One, according to Magnitude of Odds Ratios from Table 4
| Biomarkers Used to Construct the Index | Adjusted* |
Unadjusted |
||||||
|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P Value | AUC | OR | 95% CI | P Value | AUC | |
| OPN | 3.8 | 1.0–14.3 | 0.045 | 0.743 | 4.7 | 1.5–14.5 | 0.007 | 0.620 |
| OPN, SP-D | 2.5 | 1.3–4.8 | 0.008 | 0.756 | 2.9 | 1.6–5.1 | 0.0003 | 0.698 |
| OPN, SP-D, MMP-7 | 1.9 | 1.2–2.8 | 0.005 | 0.766 | 2.1 | 1.4–3.0 | 0.0001 | 0.709 |
Definition of abbreviations: AUC = area under receiver-operating characteristic curve; CI = confidence interval; MMP-7 = matrix metalloproteinase-7; OPN = osteopontin; OR = odds ratio for index comprised of markers listed in each row; SP-D = surfactant protein-D.
AUCs are shown based on separating idiopathic pulmonary fibrosis from alternative interstitial lung disease in adjusted and unadjusted analyses.
*
Adjustment variables include sex, age, smoking status, and FVC (% predicted).