Table 2.
Demographics of Healthy Control Subjects and Respiratory Syncytial Virus Cases Stratified by Nasopharyngeal Microbiome Profile
| Cluster (N = 123)* |
||||||
|---|---|---|---|---|---|---|
| HPH (n = 19) | STR (n = 32) | COR (n = 24) | MOR (n = 29) | STA (n = 19) | P Value | |
| Health status | ||||||
| Healthy | 1 (5.3) | 3 (9.4) | 7 (29.2) | 7 (24.1) | 6 (31.6) | |
| Outpatient | 4 (21.1) | 4 (12.5) | 2 (8.3) | 11 (37.9) | 1 (5.3) | |
| Inpatient | 14 (73.7) | 25 (78.1) | 15 (62.5) | 11 (37.9) | 12 (63.2) | 0.007† |
| Demographic parameters | ||||||
| Age, mo | 6.7 (3.3–8.9) | 2.5 (1.6–6.7) | 5.8 (2.4–11.7) | 5.1 (3.3–9.4) | 1.2 (0.7–2.4) | <0.0005‡ |
| Breastfeeding | 4/18 (22.2) | 2/30 (6.7) | 3/20 (15.0) | 4/27 (14.8) | 11/18 (61.1) | 0.0005† |
| Antibiotics | 11 (57.9) | 13 (40.6) | 8 (33.3) | 5 (17.2) | 3 (15.8) | 0.017§ |
| WBC/μl|| | 11.9 (9.5–17.5) | 9.4 (6.7–12.7) | 10.8 (9.3–15.1) | 10.1 (7.4–13) | 9.1 (7.9–10.9) | 0.122‡ |
| Neutrophils, % | 40.0 (34.5–58.5) | 34.0 (22.5–49.5) | 29.0 (19.5–51.0) | 25.0 (16.0–42.3) | 24.5 (19.0–32.0) | 0.006‡ |
| Lymphocytes, % | 40.0 (29.0–51.5) | 50.0 (38.5–66.0) | 57.5 (39.0–67.3) | 61.0 (47.0–72.0) | 60.0 (54.5–63.3) | 0.003‡ |
| Monocytes, % | 12.0 (8.5–15.0) | 13.0 (8.5–17.5) | 8.5 (5.0–10.3) | 9.5 (6.0–14.0) | 11.5 (6.8–13.8) | 0.044‡ |
Definition of abbreviations: COR = Corynebacterium; HPH = Haemophilus influenzae; MOR = Moraxella; STA = Staphylococcus aureus; STR = Streptococcus; WBC = white blood cells.
Data reported are median (interquartile range) or n (%). Statistically significant P values (P < 0.05) are shown in boldface. Clusters were enriched for H. influenzae, Streptococcus, Corynebacterium, Moraxella, or S. aureus.
Nine individuals could not be assigned to a large (>3 individuals) microbiota cluster.
Statistically significant differences between groups were calculated using Fisher’s exact test for categorical data.
Statistically significant differences between groups were calculated using Kruskal–Wallis test for continuous variables.
Statistically significant differences between groups were calculated using chi-square test for categorical data.
On 19 samples, no white blood cell count and differential was performed (2, 3, 2, 7, and 5 samples included in the HPH, STR, COR, MOR, and STA clusters, respectively).