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Schematic representation showing the possible mechanisms by which G6PD inhibition increases contractile protein expression. G6PD inhibition increases MYOCD expression, which in turn increases the transcription of VSMC contractile proteins. G6PD inhibition also increases PKG activity via thioredoxin reductase (TrX)-mediated thiol oxidation, which promotes the expression of miR-1 and miR-143 leading to increase of VSMC contractile protein expression.
