Table 4.
Variables from the mitogen-stimulated peripheral blood mononuclear cell phenotypes from patients with acute hepatitis A infection and healthy subjects
| Phenotypes/cytokines (PHA/LPS) | HC (n = 10) | AH (n = 8) | ALF (n = 8) | HC vs AH | HC vs ALF | AH vs ALF |
| PI of CD3+ | 133.1 ± 71.12 | 44.4 ± 25.83 | 17.48 ± 5.94 | 0.0155 | 0.0021 | 0.0426 |
| (95.19-171.0) | (22.80-65.99) | (11.24-23.72) | ||||
| CD4+CD25+FoxP3+ (%) | 17.23 ± 9.74 | 17.08 ± 5.37 | 5.99 ± 2.80 | ns | 0.0009 | 0.0003 |
| (12.03-22.42) | (12.59-21.57) | (3.65-8.33) | ||||
| CD4+CD29+CD44+ (%) | 38.63 ± 18.37 | 20.75 ± 7.82 | 10.22 ± 4.74 | 0.0062 | < 0.0001 | 0.0047 |
| (28.84-48.42) | (14.21-27.29) | (6.25-14.18) | ||||
| CD8+CD29+CD44+ (%) | 39.76 ± 19.91 | 37.56 ± 25.01 | 9.03 ± 4.59 | ns | 0.0002 | 0.0104 |
| (29.15-50.36) | (16.74-58.57) | (5.18-12.88) | ||||
| CD3-CD56+CD16- (%) | 8.31 ± 6.75 | 4.19 ± 2.28 | 0.50 ± 0.37 | ns | 0.0006 | 0.0009 |
| (2.07-14.56) | (2.08-6.30) | (0.15-0.84) | ||||
| CD3-CD56lowCD16+ (%) | 12.70 ± 8.93 | 8.52 ± 5.68 | 1.11 ± 0.66 | ns | 0.0012 | 0.0018 |
| (4.44-20.96) | (3.26-13.78) | (0.50-1.72) | ||||
| CD3+CD56+CD16+ (%) | 13.66 ± 3.54 | 7.20 ± 5.28 | 1.83 ± 1.06 | 0.0117 | < 0.0001 | 0.0070 |
| (11.77-15.55) | (2.79-11.63) | (0.94-2.72) | ||||
| IL-6 (pg/mL) | 2625.33 ± 3320 | 565.7 ± 313.3 | 156.8 ± 173.9 | 0.0155 | < 0.0001 | 0.0070 |
| (856.5-4394) | (303.8-827.6) | (11.40-302.2) | ||||
| TNFα (pg/mL) | 1675.20 ± 623.4 | 1405.0 ± 324.3 | 145.3 ± 107.9 | ns | < 0.0001 | 0.0002 |
| (1343-2007) | (1134-1676) | (55.09-235.5) | ||||
| IL-10 (pg/mL) | 528.86 ± 755.1 | 269.5 ± 145.8 | 188.4 ± 267.1 | ns | 0.0454 | ns |
| (126.5-931.2) | (147.6-391.5) | (-16.88-393.7) | ||||
| IFNγ (pg/mL) | 3379.1 ± 1869 | 2467.0 ± 2787 | 1249.0 ± 2067 | ns | 0.0205 | ns |
| (2383-4375) | (137.1-4798) | (-479.2-2977) | ||||
| IL-8 (pg/mL) | 273.9 ± 116.3 | 274.2 ± 148.5 | 151.0 ± 156.4 | ns | 0.0205 | 0.0379 |
| (211.9-335.9) | (150.0-398.3) | (20.21-281.8) | ||||
| IL-17 (pg/mL) | 73.81 ± 107.0 | 31.55 ± 35.58 | 4.16 ± 3.20 | ns | 0.0029 | 0.0116 |
| (16.81-130.8) | (1.80-61.30) | (1.49-6.84) |
The differences between the hepatitis A-induced acute liver failure (ALF) patients, the self-limited acute hepatitis A (AH) patients, and the healthy control (HC) subjects were evaluated by intergroup comparisons using the Mann-Whitney U-test. The significance cutoff for all statistical analyses was defined as P < 0.05. IL: Interleukin; IFNγ: Interferon gamma; TNFα: Tumor necrosis factor alpha; ns: Not significant; PI: Proliferation index.