Table 6.
Variables from mitogen-stimulated peripheral blood mononuclear cells from non-viral acute hepatitis patients and healthy control subjects
| Phenotypes/cytokines (PHA/LPS) | HC (n = 10) | AH (n = 8) | ALF (n = 5) | HC vs AH | HC vs ALF | AH vs ALF |
| PI of CD3+ | 133.1 ± 71.12 | 173.3 ± 91.84 | 268.4 ± 101.6 | ns | ns | ns |
| (95.19-171.0) | (96.51-250.1) | (142.3-394.5) | ||||
| CD4+CD25+FoxP3+ (%) | 17.23 ± 9.74 | 15.82 ± 8.13 | 6.84 ± 5.12 | ns | ns | ns |
| (12.03-22.42) | (9.02-22.62) | (0.48-13.2) | ||||
| CD4+CD29+CD44+ (%) | 38.63 ± 18.37 | 21.84 ± 7.50 | 36.67 ± 14.54 | ns | ns | ns |
| (28.84-48.42) | (15.56-28.11) | (18.61-54.73) | ||||
| CD8+CD29+CD44+(%) | 39.76 ± 19.91 | 22.26 ± 11.16 | 29.59 ± 15.21 | ns | ns | ns |
| (29.15-50.36) | (12.92-31.59) | (10.71-48.47) | ||||
| CD3-CD56+CD16- (%) | 8.31 ± 6.75 | 6.33 ± 4.13 | 17.22 ± 4.94 | ns | 0.0289 | 0.0030 |
| (2.07-14.56) | (2.88-9.79) | (13.09-21.35) | ||||
| CD3-CD56lowCD16+ (%) | 12.70 ± 8.93 | 11.38 ± 4.67 | 27.66 ± 3.49 | ns | 0.0061 | 0.007 |
| (4.44-20.96) | (7.05-15.71) | (22.11-33.21) | ||||
| CD3+CD56+CD16+ (%) | 13.66 ± 3.54 | 11.63 ± 3.01 | 8.52 ± 4.97 | ns | ns | ns |
| (11.77-15.55) | (9.11-14.15) | (2.35-14.70) | ||||
| IL-6 (pg/mL) | 2625.33 ± 3320 | 966 ± 622.6 | 1309 ± 851.6 | ns | ns | ns |
| (856.5-4394) | (445.5-1486.0) | (251.60-2366) | ||||
| TNFα (pg/mL) | 1675.20 ± 623.4 | 1497 ± 219.8 | 3217 ± 991.5 | ns | 0.0044 | 0.0016 |
| (1343-2007) | (1313-1681) | (1986-4448) | ||||
| IL-10 (pg/mL) | 528.86 ± 755.1 | 217.1 ± 159.1 | 152.1 ± 126.4 | ns | ns | ns |
| (126.5-931.2) | (84.12-350.2) | (-4.89-309.0) | ||||
| IFNγ (pg/mL) | 3379.1 ± 1869 | 2257 ± 2872 | 1378 ± 2533 | ns | ns | ns |
| (2383-4375) | (-143.3-4658) | (-1767-4524) | ||||
| IL-8 (pg/mL) | 273.9 ± 116.3 | 293.9 ± 120.2 | 733.1 ± 404.8 | ns | 0.0267 | ns |
| (211.9-335.9) | (193.4-394.4) | (230.4-1236) | ||||
| IL-17 (pg/mL) | 73.81 ± 107.0 | 36.31 ± 34.62 | 62.73 ± 5.78 | ns | ns | ns |
| (16.81-130.8) | (7.36-65.25) | (55.55-69.91) |
The differences between the non-viral acute liver failure (ALF) patients, the self-limited acute hepatitis (AH) patients, and the healthy control (HC) subjects were evaluated by intergroup comparisons using the Mann-Whitney U-test. The significance cutoff for all statistical analyses was defined as P < 0.05. IL: Interleukin; IFNγ: Interferon gamma; TNFα: Tumor necrosis factor alpha; PI: Proliferation index; HC: Healthy control; ns: Not significant.