Table 3. Results of literature search on zoonotic influenza viruses, 1946–2014 (n=94 publications).
| Influenza virus | Influenza subtype | Number of studies includeda | Laboratory methods usedb (number of studies) |
Number of studies detecting antibodies in study group (proportion of included studies) |
Number of studies detecting significant difference with control groupc (studies detecting significant difference with control group/total number of studies with control group) |
|---|---|---|---|---|---|
| Canine | H3N8 | 1 | MN/NT and NI (1) | 1 (1/1) | 0 (0/1) |
| Equine | H3N8 | 4 | MN/NT and HI (2) MN/NT (2) |
4 (4/4) | 0 (0/2) |
| H7N7 | 2 | MN/NT and HI (2) | 0 (0/2) | 0 (0/0) | |
| Swine | H1N1v | 35 | MN/NT and HI (3) HI and NI (6) HI (22) MN/NT (3) ELISA (1) |
32 (32/35) | 13 (13/20) |
| H1N2v | 6 | MN/NT and HI (1) HI (5) |
6 (6/6) | 5 (5/6) | |
| H2N3v | 1 | MN/NT and HI (1) | 1 (1/1) | 0 (0/1) | |
| H3N2v | 11 | MN/NT and HI (2) HI and NI (1) HI (7) ELISA (1) |
9 (9/11) | 3 (3/7) | |
| Avian | H1 | 4 | MN/NT and HI (1) MN/NT (2) Single radial analysis (1) |
1 (1/4) | 0 (0/1) |
| H2 | 5 | MN/NT and HI (2) MN/NT (2) Single radial analysis (1) |
2 (2/5) | 0 (0/1) | |
| H3 | 5 | MN/NT and HI (2) HI and NI (2) Single radial analysis (1) |
3 (3/5) | 0 (0/1) | |
| H4 | 22 | MN/NT and HI (2) HI and NI (3) MN/NT (15) HI (1) Single radial analysis (1) |
6 (6/22) | 1 (1/14) | |
| H5 (not H5N1) |
27 | MN/NT and HI (5) MN/NT and Western blot (1) MN/NT (18) HI (2) Single radial analysis (1) |
12 (12/27) | 4 (4/16) | |
| H6 | 21 | MN/NT and HI (3) MN/NT (15) HI (2) Single radial analysis (1) |
12 (12/21) | 2 (2/13) | |
| H7 | 40 | MN/NT and HI (10) HI and NI (3) MN/NT (17) HI (9) Single radial analysis (1) |
16 (16/40) | 6 (6/23) | |
| H8 | 16 | MN/NT and HI (2) HI and NI (1) MN/NT (12) Single radial analysis (1) |
2 (2/16) | 1 (1/11) | |
| H9 | 43 | MN/NT and HI (10) MN/NT and Western blot (1) HI and ELISA (1) MN/NT (17) HI (13) Single radial analysis (1) |
37 (36/43) | 13 (13/29) | |
| H10 | 19 | MN/NT and HI (3) MN/NT (13) HI (2) Single radial analysis (1) |
6 (6/19) | 1 (1/12) | |
| H11 | 19 | MN/NT and HI (2) HI and NI (3) MN/NT (12) HI (1) Single radial analysis (1) |
9 (9/19) | 0 (0/11) | |
| H12 | 14 | MN/NT and HI (2) HI and NI (1) MN/NT (9) HI (1) Single radial analysis (1) |
5 (5/14) | 0 (0/7) | |
| H13 | 4 | MN and HI (2) HI (2) |
1 (1/4) | 0 (0/1) | |
| H14 | 1 | MN and HI (1) | 0 (0/1) | 0 (0/1) | |
| H15 | 1 | MN and HI (1) | 0 (0/1) | 0 (0/1) | |
| H16 | 1 | MN and HI (1) | 0 (0/1) | 0 (0/1) |
ELISA: enzyme-linked immunosorbent assay; HI: haemagglutination inhibition assay; MN: microneutralisation assay; NI: neuraminidase inhibition assay; NT: neutralisation test.
a A given article could describe more than one study design, animal species, or influenza A subtype, so the total number of studies in this column is greater than 94.
b More detailed information can be found in the supplementary table (http://www.erasmusmc.nl/viroscience/research/suppl-table-animal-influenza-human-serology.pdf/?view=active).
c Studies in which a significant difference was explicitly mentioned or for which a significant difference could be calculated based on the data provided.