Table 1.

Levels of Immunosuppression Based Upon Strength of Immunosuppressive Medication

High-Level Immunosuppression

Treatment with glucocorticoids (prednisone >20 mg/day for ≥2 weeks and within 3 months of stopping therapy)

Treatment with effective doses of 6-mercaptopurine, azathioprine, or methotrexate compared with those with low-level immunosuppression (described below) or discontinuation within 3 months

Treatment with adalimumab, certolizumab pegol, golimumab, infliximab, natalizumab, or vedolizumab, or recent discontinuation within 3 months

Low-Level Immunosuppression

Treatment with lower total daily doses of corticosteroids compared with those with high-level immunosuppression for more than 14 days

Patients receiving methotrexate (<0.4 mg/kg/week), azathioprine (<3.0 mg/kg/day), or mercaptopurine (<1.5 mg/kg/day)