Fig. 2.

Schematic overview of the methodological steps taken.

1. Selecting one minute of ioECoG near the end of the recording to minimize propofol effects.

2. Visual marking of spikes, ripples and fast ripples with corresponding screen settings.

3. Selecting four epileptic event- and artifact free epochs of 2 s for functional network analysis.

4. Computing the PLI between each pair of bipolar electrode channels in the FR-, ripple-, gamma- and theta frequency band

5. Constructing graphs and calculating the strength and eigenvector centrality of each node for different frequency bands and comparing the spatial relation with epileptic event rates.