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. 2016 Nov 18;6:36698. doi: 10.1038/srep36698

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Copyright © 2016, The Author(s)

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(a) Animal experimental design. Mice were randomized into 5 groups to receive vehicle, folic acid (FA) and/or Tanshinone IIA (TS) given on day 1 [FA+TS(E)] or day 5 [FA+TS(L)] after folic acid injury; (b) Time course changes of serum creatinine levels (mg/dl) measured on days 0, 1, 3, 5, 7, 14 and 28; ^*P < 0.001, FA+TS(E) vs FA; ^#P < 0.001 FA+TS(E) vs FA+TS(L); ^$P < 0.001, FA+TS(L) vs FA; ^△P = 0.017, FA+TS(E) vs FA; ^@P = 0.018, FA+TS(L) vs FA; (n = 9). (c) Kidney to body weight ratios were determined on day 28. ^◊P < 0.001 vs Control; ^★P < 0.001 vs TS; ^▲P = 0.004 vs FA; ^☆P = 0.024 vs FA; n.s., not significant; (n = 9).