Figure 3. Focal knockdown of spinal Tet1 alleviates SNL-enhanced dorsal horn neuron excitability.

(a–c) EIectrophysiological recording traces and statistical analyses shown that compared with the sham operation, SNL increased the frequency and amplitude of mEPSCs of dorsal horn neurons that were reversed by daily administration with Tet1 mRNA-targeting, but not antisense siRNA. Scale bar = 30 pA, 300 ms. **P < 0.01 vs. Sham 7D. ^##P < 0.01 vs. SNL 7D. n = 5.