Table 2. Calcium signaling pathway and its association with LAD and LVA using two enrichment tools.

Enrichment tool	Phenotype	C	O	E	R	rawP	adjP
WebGestalt	LAD	177	85	27.12	3.13	1.2E-24	2.7E-22
	LVA		70	23.5	2.98	2.4E-18	5.5E-16
GATHER	LAD	196	88			4.0E-05	5.2E-03
	LVA		73			1.2E-04	1.5E-02

C, the number of reference genes in the category; O, the number of genes in the gene set and also in the category; E, expected number in the category; R, the ratio of enrichment, rawP, the p value from hypergeometric test (Webgestalt) or Fisher’s exact test (GATHER); adjP, the p value adjusted by the multiple test adjustment. Please note that GATHER does not provide E and R.