Figure 2.

Relative impacts of drift and Pool‐Seq‐associated sampling. Neutral simulations assuming 202 isofemale lines show that allele frequency change (AFC) due to genetic drift only (drift) is expected to be weak, whereas Pool‐Seq (modeled as a round of binomial sampling on allele counts after drift) is responsible for an inflation of AFC that decreases with higher coverage values. Empirical AFC is computed using coverage values from the Drosophila simulans populations (see Table 1).