Table 3.
Differentially expressed protein coding genes (mRNA) showing the highest fold changes (in either direction) in kidney samples of the Ins2 Akita mice in the diabetic (D) and P78 treatment (T) groups
| Increased | Decreased | ||
|---|---|---|---|
| Gene | Fold change | Gene | Fold change |
| A | |||
| Nhej1 | 32.04 | Srd5a2 | −6.55 |
| Ept1 | 8.6 | Aif1 | −6.05 |
| Cyp4a14 | 4.44 | Angptl7 | −4.71 |
| A@7ip | 4.21 | Thrsp | −4.57 |
| Foxn3 | 2.92 | Ucp1 | −4.35 |
| Txnrd1 | 2.76 | Lypd2 | −4.2 |
| Gldc | 2.44 | Ugt1a2 | −4.13 |
| Cyp4a12b | 2.4 | Ly6e | −3.77 |
| Sulf2 | 2.37 | Scd1 | −3.7 |
| Kdm4b | 2.28 | Inmt | −3.42 |
| Suco | 2.28 | Ang | −3.24 |
| Cyp4a10 | 2.27 | Cyp2d12 | −2.94 |
| Aldh1a7 | 2.21 | Anxa13 | −2.92 |
| Slc18b1 | 2.04 | Car9 | −2.89 |
| Reep6 | 1.97 | Mamdc4 | −2.85 |
| Gsta2 | 1.95 | Cox8b | −2.77 |
| Zbtb18 | 1.94 | Tmem86a | −2.64 |
| Slc38a3 | 1.93 | Il34 | −2.57 |
| Akr1d1 | 1.91 | Ramp3 | −2.51 |
| Etf1 | 1.86 | Acsm3 | −2.5 |
| ApoB | 1.85 | Gusb | −2.48 |
| Erlin1 | 1.8 | Hsd17b11 | −2.43 |
| Pklr | 1.78 | Cyp4b1 | −2.35 |
| Folh1 | 1.77 | Rarres2 | −2.32 |
| Cfd | 1.71 | Lipo1 | −2.32 |
| Huwe1 | 1.7 | Nudt19 | −2.28 |
| Itgb6 | 1.69 | Cck | −2.28 |
| Cyp4a31 | 1.65 | H2-Ab1 | −2.27 |
| Mtus1 | 1.65 | Tmem37 | −2.22 |
| Selm | 1.64 | Eri2 | −2.2 |
| Ccng1 | 1.64 | C1qtnf3 | −2.18 |
| C3 | 1.61 | Rhod | −2.18 |
| Enpep | 1.6 | Stab1 | −2.14 |
| Mgst1 | 1.56 | Hsd11b1 | −2.13 |
| B | |||
| Tceanc2 | 5.76 | Nhej1 | −37.94 |
| Ugt1a2 | 3.03 | Ept1 | −4.45 |
| Mamdc4 | 2.81 | Tmsb15l | −3 |
| Plk3 | 2.68 | Kdm4b | −2.8 |
| Lars2 | 2.57 | Selm | −2.47 |
| Sgk1 | 1.76 | Cyp4a14 | −2.22 |
| Tmem252 | 1.75 | Cyp24a1 | −2.02 |
| Adck5 | 1.72 | Alox5ap | −1.92 |
| Psmd13 | 1.68 | Etf1 | −1.71 |
| Chic2 | 1.67 | Hba-a1 | −1.54 |
| Slc25a25 | 1.61 | Odc1 | −1.52 |
| Vps39 | 1.61 | Hbb‐bs | −1.51 |
| Hacl1 | 1.6 | ||
| Gcn1l1 | 1.57 | ||
| Hpd | 1.57 | ||
| Acnat2 | 1.54 | ||
| Fkbp5 | 1.5 | ||
| C | |||
| Gene | DvC | TvD | |
| Nhej1 | 32.04 | −37.94 | |
| Ept1 | 8.6 | −4.45 | |
| Cyp4a14 | 4.44 | −2.22 | |
| Ugt1a2 | −4.13 | 3.03 | |
| Mamdc4 | −2.85 | 2.81 | |
| Kdm4b | 2.29 | −2.8 | |
| Etf1 | 1.86 | −1.71 | |
| Chic2 | −1.85 | 1.67 | |
| Tmem252 | −1.67 | 1.75 | |
| Selm | 1.64 | −2.47 | |
| Fkbp5 | −1.6 | 1.5 | |
| Hpd | −1.58 | 1.57 | |
A. All protein-coding genes with increased or decreased expression levels by FC > (+/-)1.5 (q < 0.05) in diabetic relative to wt control B. All coding genes upregulated or downregulated by P78 treatment with FC > =(+/-)1.5 (q < 0.05) relative to diabetic controls. C. All coding genes with FC > (+/-)1.5 (q < 0.05) that were reverted in their expression towards normal levels by P78 treatment (TvD, early and late treatment). Genes are rank ordered by FC (positive or negative values)