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. Author manuscript; available in PMC: 2017 Oct 15.
Published in final edited form as: Bioorg Med Chem. 2016 Jul 21;24(20):4768–4778. doi: 10.1016/j.bmc.2016.07.039

Figure 5.

Figure 5

Computed structure for JLJ494, the dichloro analogue of 21, bound to WT HIV-RT. Note the expected ‘down’ orientation of Tyr181 and hydrogen bonds between the uracilyl OCNH fragment and the backbone NH and CO of Lys103.