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. 2016 Aug 25;15(6):1132–1139. doi: 10.1111/acel.12520

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© 2016 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Increased fiber death in GPA‐induced ETC abnormal fibers. (A) Representative ETC abnormal fiber undergoing apoptosis and necrosis in a GPA‐treated rat. Dual and single histochemical staining for COX and SDH. Immunohistochemical staining for cl‐Cas3 and c5b‐9. The scale bar denotes 50 μm. (B) A greater fraction of ETC abnormal fibers are positive for apoptotic (cl‐Cas3) and necrotic (c5b‐9) cell death in GPA‐treated rat muscle as compared to control. (C) Cell death processes are activated in shorter ETC abnormal fiber segments of GPA‐treated rats than in controls.