Fig. 1.

Follow-up algorithms. For each subsite TSH annually, smoking and alcohol cessation suggested to all patients. Clinical examination according to National Comprehensive Cancer Network should include ear, nose and throat evaluation, pain/xerostomia/depression management, nutritional support, dental care, and speech and swallowing therapy. All CT scan and MRI are considered with contrast. Patients with PS >2, or with comorbidity that contraindicate treatment are not followed up for the disease. TNM, tumor-node-metastasis; CT, computed tomography; MRI, magnetic resonance imaging; PET, positron emission tomography; PS, performance status; TSH, thyroid stimulating hormone; CRT, chemoradiation; M, months; NFE, nasal/pharyngo/laryngeal fiber optic examination; ACF, anterior cranial fossa; MCF, medial cranial fossa; vc, vocal cord. ^a)If doubt of recurrence or metastatic disease. ^b)If smoking history >20 pack year. ^c)T3-4 close margin.