Table 1.
Polychoric Correlation | Sensitivity (%) | 95% CI | Specificity (%) | 95% CI | PPV (%) | 95% CI | NPV (%) | 95% CI | LR+ | 95% CI | LR− | 95% CI | AUC ROC | 95% CI | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Crossmatcha | |||||||||||||||
TUBE vs. MICRO | 0.97 | 85.71 | 73.78–93.62 | 96.67 | 90.57–99.31 | 94.12 | 83.76–98.77 | 91.58 | 84.08–96.26 | 25.74 | 8.40–78.63 | 0.15 | 0.08–0.28 | 0.91 | 0.86–0.96 |
TUBE vs. GEL (Agglutination) | 0.882 | 91.07 | 80.38–97.04 | 82.22 | 72.74–89.48 | 76.12 | 64.14–85.69 | 93.67 | 85.84–97.91 | 5.12 | 3.26–8.05 | 0.11 | 0.05–0.25 | 0.9 | 0.85–0.95 |
TUBE vs. GEL (Hemolysin) | 0.834 | 28.57 | 13.22–48.67 | 99.15 | 95.37–99.98 | 88.89 | 51.75–99.72 | 85.4 | 78.36–90.85 | 33.71 | 4.39–260.00 | 0.72 | 0.57–0.91 | 0.64 | 0.55–0.72 |
TUBE vs. PREDICTED | 0.943 | 69.64 | 55.90–81.22 | 98.89 | 93.96–99.97 | 97.5 | 86.84–99.94 | 83.96 | 75.57–90.37 | 62.68 | 8.86–440.00 | 0.31 | 0.21–0.46 | 0.85 | 0.78–0.90 |
Ca Blood Typingc | |||||||||||||||
Standard vs. STRIP | 1 | 100 | 87.66–1b | 100 | 96.92–1b | 100 | 87.66–1b | 100 | 96.92–1b | Inf | N/A | 0.00 | N/A | 1 | 1.00–1.00 |
bOne‐sided 97.5% CI |
aTest method as compared to standard tube crossmatch as reference value for 146 recipient‐donor pairs. bOne‐sided 97.5% confidence interval (CI). TUBE, tube crossmatch by standard gross macroscopic assessment of agglutination. MICRO, microscopic assessment of agglutination, tube method. GEL, crossmatch by gel column technique. PREDICTED, compatibility as predicted by prior blood type and alloantibody assays. Standard, Standard polyclonal blood typing assay. STRIP, immunochromatographic strip Ca blood typing kit. cImmunochromatographic strip method as compared to standard blood typing for Ca antigen as reference value. A value of 1 for polychoric correlation indicates perfect correlation. Prevalence of incompatible blood by TUBE agglutination was 38% (56/146). Prevalence of incompatible blood by TUBE hemolysis was 19% (28/146). Prevalence of Ca+ blood type was 92% (35/38).