Table 1.

Patient Demographics

Variables		Training Cohort (n=60)		Test Cohort (n=120)		Validation Cohort (n=150)

Controls

Age	Mean ± SD	51 ± 11		40 ± 18		53 ± 20
Age	Median (range)	55 (27 – 63)		29 (21 – 73)		64 (22 – 74)

Gender	Male	6		12		9
Gender	Female	4		8		16

Race	Caucasian	10		16		23
	African American	0		4		2
	Asian	0		0		0

Colorectal Cancer

Age	Mean ± SD	55 ± 8		63 ± 8		59 ± 11
Age	Median (range)	55 (44 – 67)		62 (47 – 76)		59 (26 – 77)

Gender	Male	5		10		12
Gender	Female	5		10		13

Race	Caucasian	10		20		24
	African American	0		0		1
	Asian	0		0		0

Colorectal Adenoma

Age	Mean ± SD	64 ± 8		59 ± 12		63 ± 14
Age	Median (range)	63 (51 – 77)		59 (38 – 79)		64 (42 – 89)

Gender	Male	5		6		8
Gender	Female	5		14		17

Race	Caucasian	10		14		19
	African American	0		4		5
	Asian	0		2		1

Breast Cancer

Age	Mean ± SD	60 ± 10		53 ± 13		57 ± 9
Age	Median (range)	59 (48 – 79)		53 (29 – 79)		56 (39 – 77)

Gender	Male	0		0		0
Gender	Female	10		20		25

Race	Caucasian	10		18		24
	African American	0		2		1
	Asian	0		0		0

Pancreatic Cancer

Age	Mean ± SD	59 ± 6		65 ± 9		67 ± 9
Age	Median (range)	60 (49 – 69)		62 (49 – 86)		67 (51 – 86)

Gender	Male	5		8		11
Gender	Female	5		12		14

Race	Caucasian	10		20		23
	African American	0		0		2
	Asian	0		0		0

Lung Cancer

Age	Mean ± SD	58 ± 7		62 ± 10		58 ± 11
Age	Median (range)	60 (44 – 66)		62 (44 – 81)		56 (36 – 79)

Gender	Male	5		11		11
Gender	Female	5		9		14

Race	Caucasian	8		17		23
	African American	2		3		2
	Asian	0		0		0

American Joint Committee on Cancer Stage		Study Subjects
American Joint Committee on Cancer Stage		Colorectal Cancer (n=55)	Breast Cancer (n=55)	Pancreatic Cancer (n=55)	Lung Cancer (n=55)	Colorectal Advanced Adenoma (n=55)	Controls (n=55)

0		4	4	2	4	Not applicable >0.6cm tubulovillous or villous	Not applicable

I		9	22	5	19

II		22	16	31	14

III		5	9	7	13

IV		12	2	6	1

Not available		3	2	4	4