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. Author manuscript; available in PMC: 2017 Jul 30.
Published in final edited form as: Int Rev Cell Mol Biol. 2016 Jul 30;327:195–261. doi: 10.1016/bs.ircmb.2016.06.004

Figure 2. Membrane microdomains in T cell activation.

Figure 2

(A) Diagram showing plasma membrane subdomains regulated by the action of proteins like tetraspanins, caveolins, MAL, and Flotillins. GPI- and acyl-proteins also localize to specific microdomains at the membrane. (B) TCR-activation pathways. Upon TCR recognition of a peptide-charged MHC, the TCR/CD3 complex undergoes conformational changes (not depicted) that initiate its activation.