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. Author manuscript; available in PMC: 2017 Jul 30.
Published in final edited form as: Int Rev Cell Mol Biol. 2016 Jul 30;327:195–261. doi: 10.1016/bs.ircmb.2016.06.004

Figure 3. Intracellular traffic and activation at the IS.

Figure 3

TCR recycling is important for a sustained T-cell signaling. TCR complex is endocytosed by the formation of Rab4- and Rab11-bearing vesicles. They are transported along the MTs toward the MTOC or centrosome. Once in the proximity of the IS they fuse in a VAMP3-dependent manner. Lck and LAT also have an intracellular pool that docks at the IS. Different IFT proteins form large complexes that are in charge of TCR/CD3 recycling through Rab11- bearing vesicles.