Table 3. Ribotypes, gyrA and gyrB mutations, and antimicrobial susceptibility of 18 Clostridium difficile isolates with binary toxin.
Isolate No. | Ribotype (RT) | gyrA mutation | gyrB mutation | MIC, mg/L | ||
---|---|---|---|---|---|---|
MX | MZ | VA | ||||
2 | RT 328 | - | - | 0.5 | 0.032 | 0.5 |
286 | RT 034 | - | - | 0.5 | 0.064 | 0.5 |
294 | - | Asp426Asn | >32 | 0.125 | 0.5 | |
381 | - | - | 0.5 | 0.032 | 0.25 | |
80 | RT 078 | - | - | 0.25 | 0.032 | 0.38 |
61 | RT 126 | Thr82Ile | - | >32 | 0.032 | 0.25 |
173 | Thr82Ile | - | >32 | 0.032 | 0.5 | |
203 | - | - | 0.5 | 0.032 | 0.75 | |
264 | - | - | 0.5 | 0.047 | 0.75 | |
7 | RT 127 | Thr82Ile | - | >32 | 0.032 | 0.38 |
15 | Thr82Ile | - | >32 | 0.032 | 0.38 | |
16 | Thr82Ile | - | >32 | 0.032 | <0.016 | |
17 | Thr82Ile | - | >32 | <0.016 | 0.38 | |
92 | - | - | 0.38 | 0.032 | 0.38 | |
293 | Thr82Ile | - | >32 | 0.023 | 0.38 | |
9 | Unknown | Thr82Ile | - | >32 | 0.032 | 0.38 |
13 | Thr82Ile | - | >32 | 0.032 | 0.38 | |
14 | - | - | 0.1 | 0.047 | <0.016 |
MX: moxifloxacin; MZ: metronidazole; VA: vancomycin.