Table 1. Comparison of distribution (%) of variant allele carriers of candidate SNPs among groups.

	Severe sepsis cases (n = 47)	Non-severe sepsis cases (n = 61)	Significance (severe vs. non-severe sepsis cases)	Febrile de-compensated cirrhotic patients (n = 108)	Afebrile compensated cirrhotic patients (n = 51)	Significance (febrile vs. afebrile cases)	Healthy controls (n = 121)	Significance (healthy controls vs. afebrile cases)
TLR4 +896A/G	16 (34%) ##,**	15(25%) #	<0.001	31(29%) ‡	10(20%)	0.018	17(14%) ‡	0.04
G–allele carriers			3.7 [0.23–4.25]			2.13 [1.302–4.908]		2.05 [1.34–5.17]
TLR4 3′UTR, G/C	10(21%)	12(20%)	0.28	22(20%)	8(16%)	0.15	13(11%)	0.08
C–allele carriers			1.89 [0.65–5.96]			1.28 [0.49–3.82]		1.23 [0.57–2.69]
CD14 -159C/T	18 (38%) ##,**	15(25%) #	<0.001	33(31%) ‡	12(24%)	0.029	21(17%) ‡	0.032
T-allele carriers			2.7 [1.1–3.9]			1.98 [1.234–8.214]		1.75 [1.07–4.23]
CD14 3′UTR,C/A	8(17%)	9(15%)	0.15	17(16%)	7(14%)	0.36	13(11%)	0.19
A-allele carriers			1.47 [0.94–2.3]			0.89 [0.22–3.36]		1.06 [0.78–1.43]
TNFα -308G/A	14 (30%) #	16 (26%)	0.305	30(28%)	14(27%)	0.31	28(23%)	0.166
A-allele carriers			1.01 [099–1.028]			1.16 [1.25–5.13]		1.27 [0.94–1.73]

Cases: de-compensated cirrhotic patients; categorical variables were expressed as case number and percentage [%, case No. of variant allele carrier/variant+wild-type allele carriers] of variant alleles carriers; the unlisted case No. (%) of corresponding wild-type allele carriers were case number in different groups minus variant allele carriers {100-[% of variant allele carriers]}; severe sepsis/non-severe sepsis cases: febrile de-compensated cirrhotic patients with severe sepsis/without severe sepsis

^#P <0.01 &

^##P <0.001 vs. healthy controls

*P <0.01 &

**P <0.001 vs. non-severe sepsis cases.

‡P<0.05 vs. afebrile compensated cirrhotic patients; Descriptive significance between groups were showed as P-value [odd ratio, OR (95% confidence interval, CI)].