Table 2. Characteristics of febrile acute de-compensated cirrhotic patients with variant/wild-type allele carriers (variant/wild-type).

Different carrier of TLR4 +896A/G polymorphism	variant allele (n = 22)	wild-type allele (n = 86)	P values
Gender (male/female) ratio	15/7 (68/32%)	62/24 (72/28%)	0.35
Child-Pugh class (A/B+C) (%)	5/17(13/77%)	19/67(22/78%)	0.48
Severity of ascites (no+mild/moderate+massive)(%)	9/13(41/59%)	40/46(47/53%)	0.65
Model of end stage liver disease (MELD) score	17.9± 6.4	19.3± 4.1	0.33
Acute physiologic and chronic health (APACH) III score	22.1 ±5.9	19.8± 6.5	0.24
[C-reactive protein, (CRP)] mg/dL	4.1±1.1	3.9 ±1.7	0.41
[sCD14] μg/mL	6.9±0.5*	3.7±0.4	0.002
[IL-10] pg/mL	17.5 ±2.2*	9.7±1.4	0.01
[total nitric oxide (NOx)] μM	38.5± 3.5*	19.3 ±8.7	0.005
Previous spontaneous bacterial peritonitis (SBP)	10(45%)**	29(34%)	<0.001
Percentage of cases complicated with severe sepsis (%)	13(59%)*	27(31%)	0.005
Different carrier of CD14 -159C/T polymorphism	variant allele (n = 33)	wild-type allele (n = 75)
Gender (male/female) ratio	22/11(67/33%)	55/20(73/27%)	0.95
Child-Pugh class (A/B+C) (%)	5/28(15/85%)	19/56(25/75%)	0.69
Ascites (no+mild/moderate+massive)(%)	13/20(39/61%)	36/39(48/52%)	0.38
MELD score	18.3± 2.5	18.4± 5.6	0.52
APACH III score	22.3 ±5.4	24.1±6.3	0.29
[CRP] mg/dL	5.7±1.9	4.6 ±2.1	0.26
[sCD14] μg/mL	4.7±0.8*	1.5±0.4	0.003
[IL-10] pg/mL	16.8 ±1.3	14.3±5.7	0.15
[NOx] μM	37.5 ±2.9*	21.4 ±6.8	0.012
Previous SBP	13(39%)**	21(28%)	<0.001
Percentage of cases complicated with severe sepsis (%)	14(42%)*	23(31%)	0.026

Data are mean±SD; categorical variables were expressed as case number [percentage (%) of frequency]

*P <0.01

**P <0.001 vs. TLR4 +896 A/G&CD14 -159C/T, wild-type allele carriers.